Immunosuppressive effects of mesenchymal stem cells: Involvement of HLA-G
01/07/2007
Titre de la revue : Transplantation Volume : 84 N° : 2 Pagination : 231-237 Date de publication : 01/07/2007
Type de document >
*Article de revue
Unité de recherche >
IRSN/DRPH/SRBE/LTCRA
Auteurs >
BOUCHET Sandrine
,
BOUTARFA Asma
,
CHAPEL Alain
,
FOUILLARD Loïc
,
FRANCOIS Sabine
,
FRICK Johanna
,
GORIN Norbert Claude
,
MATHIEU Noëlle
,
MAZURIER Christelle
,
NASEF Aisha
,
THIERRY Dominique
Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties. They are able to suppress allogenic T-cell response and modify maturation of antigen-presenting cells. Their role in the treatment of severe graft versus host disease has been reported. The underlying molecular mechanisms of immunosuppression are currently being investigated. Histocompatibility locus antigen (HLA)-G is a nonclassical major histocompatibility complex class I antigen with strong immune-inhibitory properties.
Migration content title
En savoir plus
Migration content text
Migration content title
Texte complet
Migration content text
Migration content title
Contact
Migration content text